Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila
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منابع مشابه
Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila
Notch is the receptor for a conserved signaling pathway that regulates numerous cell fate decisions during development [1]. Signal transduction involves the presenilin-dependent intracellular processing of Notch and the nuclear translocation of the intracellular domain of Notch, NICD [2-6]. NICD associates with Suppressor of Hairless [Su(H)], a DNA binding protein, and Mastermind (Mam), a trans...
متن کاملMolecular Analysis of the Notch Repressor-Complex in Drosophila: Characterization of Potential Hairless Binding Sites on Suppressor of Hairless
The Notch signalling pathway mediates cell-cell communication in a wide variety of organisms. The major components, as well as the basic mechanisms of Notch signal transduction, are remarkably well conserved amongst vertebrates and invertebrates. Notch signalling results in transcriptional activation of Notch target genes, which is mediated by an activator complex composed of the DNA binding pr...
متن کاملHairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless
Cell fate choices during metazoan development are driven by the highly conserved Notch signalling pathway. Notch receptor activation results in release of the Notch intracellular domain (NICD) that acts as transcriptional co-activator of the DNA-binding protein CSL. In the absence of signal, a repressor complex consisting of CSL bound to co-repressors silences Notch target genes. The Drosophila...
متن کاملHairless to recruit the corepressors Groucho and dCtBP to Suppressor of Default repression and Notch signaling: Hairless acts as an adaptor
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متن کاملDefault repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.
The DNA-binding transcription factor Suppressor of Hairless [Su(H)] functions as an activator during Notch (N) pathway signaling, but can act as a repressor in the absence of signaling. Hairless (H), a novel Drosophila protein, binds to Su(H) and has been proposed to antagonize N signaling by inhibiting DNA binding by Su(H). Here we show that, in vitro, H directly binds two corepressor proteins...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00224-x